Garmisch is less than an hour by car from Munich, and the ride is a beautiful stretch of Autobahn, unfortunately not the whole way. Expect to drive up to three hours on weekends and public holidays.
Also, trains leave to and from Munich every hour, and the beautiful ride lasts roughly 80-90 minutes on the local and 60 minutes on the express.
It is also a great end to a Romantic Road day trip beginning in Rothenburg, driving down the Romantic Road stopping at the various recommended heritage towns and ending in Garmisch for an overnight stay; or better still, a few days as it is a great base to drive out and back to Fussen [King Ludwig's castles] and Innsbruck along some of the most spectacular mountain drives you will ever see.
